Yayoi's journey as a manga artist began when she was just a teenager. She started creating her own manga and submitting them to various contests and online platforms. Her big break came in 2006 when her one-shot manga "Kimi ni Todoke" was published in the Japanese manga magazine "Shueisha's Bessatsu Margaret." The story follows Sawako Kuronuma, a high school student who becomes friends with a popular boy in her class, Shota Kazehara, and the relationships that develop around them.