Any site instructing you to "disable your antivirus before running the setup" should be treated with extreme suspicion.

A true hero protects the innocent—and that includes protecting themselves. The real amazing choice is to be patient, be smart, and be legal. Vote for the game on GOG's Dreamlist, hunt for a physical copy, or dive into the incredible, officially available Marvel's Spider-Man series on PC. Your digital peace of mind is worth more than any cracked file. Stay safe out there, and happy (legal) gaming!